gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
EGFRt is a safety tag; the CAR T cells do not target EGFR/EGFRt. EGFRt-expressing cells (the CAR T cells themselves) can be ablated only if cetuximab is given, via antibody-dependent cellular cytotoxicity.
enzyme_product
Off
epitope
On
variant
On
isoform
On
hla_specific
Off
gated
Off
other_modifier
Safety switch tag enabling cetuximab-mediated ADCC ablation; lacks ligand-binding and kinase activity
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06447987
disease_id_num_tar_ref
837
drug_id_num_tar_ref
2309