gene_symbol
CCR8
hgnc_id
HGNC:1609
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The antibody binds CCR8 on Tregs and engages Fcγ receptors on effector cells, inducing ADCC/ADCP to deplete CCR8+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPCR on intratumoral Tregs; Fc-mediated depletion (ADCC/ADCP) and blockade of CCL1–CCR8 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05935098
disease_id_num_tar_ref
841
drug_id_num_tar_ref
2318