gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific T-cell engager binds CD30 on target cells and CD3 on T cells, forming an immune synapse that activates TCR/CD3 signaling; redirected CTLs kill CD30+ cells via perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated surface antigen on CD30+ malignancies
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06018129
disease_id_num_tar_ref
850
drug_id_num_tar_ref
2340