gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
T-DXd binds HER2 (not topoisomerase I); after HER2-mediated internalization, the deruxtecan payload inhibits topoisomerase I causing DNA damage and cell death, with possible bystander killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload enzyme target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06245824
disease_id_num_tar_ref
856
drug_id_num_tar_ref
2355