gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and recruits Fc receptor-bearing immune cells to kill HER2+ cells via ADCC (with possible CDC); HER2 signaling blockade can also promote apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain IV of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05749900
disease_id_num_tar_ref
858
drug_id_num_tar_ref
2359