gene_symbol
PDCD1
hgnc_id
HGNC:8760
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The engineered T cells kill CD19+ B cells via STAR-receptor redirected TCR/CD3 signaling and perforin/granzyme cytotoxicity. PD-1 is knocked out on the therapeutic T cells and is not a killing target; PD-1-expressing cells are not directly attacked.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CRISPR knockout in therapeutic T cells to prevent checkpoint inhibition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06321289
disease_id_num_tar_ref
860
drug_id_num_tar_ref
2364