gene_symbol
TRAC
hgnc_id
HGNC:12029
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The product T cells kill CD19+ B cells via a STAR receptor that redirects TCR–CD3 signaling (perforin/granzyme cytolysis). TRAC is knocked out as an editing site and is not a killing target; cells expressing TRAC are not targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CRISPR knockout to remove endogenous TCR and reduce GvHD
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06321289
disease_id_num_tar_ref
860
drug_id_num_tar_ref
2364