gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2, is internalized, and releases the DM1 payload that disrupts microtubules causing mitotic arrest and apoptosis; Fc engagement can also mediate ADCC against HER2-positive cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05673928
disease_id_num_tar_ref
866
drug_id_num_tar_ref
2379