gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
T-DM1 targets HER2 on the cell surface; after HER2-mediated internalization, the DM1 payload binds tubulin beta and disrupts microtubules, causing mitotic arrest and apoptosis in HER2-overexpressing cells. Tubulin itself is not the targeted antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of DM1 payload (maytansinoid); binds beta-tubulin to disrupt microtubules
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05673928
disease_id_num_tar_ref
866
drug_id_num_tar_ref
2379