gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Inhibits HER2 kinase activity, blocking autophosphorylation and downstream PI3K/AKT and MAPK signaling, leading to growth arrest and apoptosis of HER2-dependent tumor cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ATP-competitive, highly selective inhibition of the HER2 kinase domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05673928
disease_id_num_tar_ref
866
drug_id_num_tar_ref
2380