gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2, is internalized, and releases MMAE that inhibits microtubule polymerization causing G2/M arrest and apoptosis; the IgG1 Fc can also mediate ADCC.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
membrane receptor tyrosine kinase; ADC antibody binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06233864
disease_id_num_tar_ref
875
drug_id_num_tar_ref
2394