gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the patient-specific peptide–HLA class I complex via their TCR, triggering cytotoxic effector functions (perforin/granzyme release and Fas–FasL–mediated apoptosis) that kill the target-expressing cells.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-restricted pMHC target; peptide sequence and source antigen are individualized (neoantigen or tumor-associated antigen) based on the patient’s lesion
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05811975
disease_id_num_tar_ref
878
drug_id_num_tar_ref
2404