gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds MET on target cells and its IgG1 Fc engages Fcγ receptors on NK cells and macrophages to trigger ADCC and ADCP, resulting in lysis/phagocytosis of MET-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain (ECD) of receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06632236
disease_id_num_tar_ref
905
drug_id_num_tar_ref
2462