gene_symbol
BIRC5
hgnc_id
HGNC:593
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TIL TCRs recognize Survivin (BIRC5)-derived peptides presented on MHC; antigen recognition triggers cytotoxic degranulation (perforin/granzymes) and death-receptor signaling (e.g., FasL), inducing apoptosis of the target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Tumor-associated antigen; presented by HLA class I/II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06463522
disease_id_num_tar_ref
94
drug_id_num_tar_ref
243