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gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on tumor cells and engages FcγR-bearing immune effectors to mediate ADCC (NK cells) and ADCP (macrophages), leading to killing of HER2-expressing cells; also blocks HER2 signaling but cytotoxicity is via Fc-mediated effector functions.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain II epitope (dimerization interface)
trial_id_tar_ref
drug_id_tar_ref
nct_id_tar_ref
NCT06435429
disease_id_num_tar_ref
918
drug_id_num_tar_ref
2498