gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2, is internalized, and releases SN-38, a topoisomerase I inhibitor that induces DNA damage and apoptosis in the TROP-2–expressing cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein; bound by hRS7 antibody component to enable ADC internalization and payload release.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05332561
disease_id_num_tar_ref
920
drug_id_num_tar_ref
2509