gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets TROP-2 on tumor cells; after internalization it releases SN-38, which inhibits topoisomerase I to cause DNA damage and apoptosis. Topoisomerase I is the intracellular payload target, not the binding antigen, so its expression alone does not make cells targeted for killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
SN-38 payload stabilizes TOP1–DNA covalent complexes, causing DNA breaks and apoptosis.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05332561
disease_id_num_tar_ref
920
drug_id_num_tar_ref
2509