gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 antibody binds HER2 and engages Fcγ receptors on immune effectors (e.g., NK cells) to mediate ADCC/ADCP, killing HER2+ cells; blockade of HER2 dimerization also promotes apoptosis via signaling inhibition.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds domain II of the HER2 extracellular domain (dimerization arm), blocking HER2 heterodimerization and mediating ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05332561
disease_id_num_tar_ref
920
drug_id_num_tar_ref
2511