gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its Fc engages Fcγ receptors on immune effectors (e.g., NK cells), inducing ADCC (and some CDC), leading to killing of EGFR+ cells; signaling blockade itself is mainly cytostatic.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain (domain III) binding; blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05873972
disease_id_num_tar_ref
930
drug_id_num_tar_ref
2535