gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccine peptides are taken up by dendritic cells and presented on MHC I/II, expanding neoantigen-specific CD8+ T cells that recognize neoepitope–MHC I on tumor cells and kill them via perforin/granzyme and Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Somatic mutation–derived peptides; multiple epitopes per patient; allele-restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT03807102
disease_id_num_tar_ref
97
drug_id_num_tar_ref
253