gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 mAb binds CD38 on target cells and induces complement-mediated lysis (CDC), Fc-mediated ADCC/ADCP by immune effectors, and apoptosis, depleting CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Ectoenzyme (NADase/ADP-ribosyl cyclase) inhibition; modulates NAD/adenosine signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05671757
disease_id_num_tar_ref
938
drug_id_num_tar_ref
2561