gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc engages CD16A on NK cells/macrophages to drive ADCC, plus CDC and direct apoptosis of CD20+ cells. CD16A-expressing effector cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated Fc enhances binding to FCGR3A, mediating ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06474481
disease_id_num_tar_ref
939
drug_id_num_tar_ref
2563