gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax binds and inhibits BCL-2, restoring mitochondrial apoptosis (BAX/BAK activation, MOMP, cytochrome c release, caspase activation) in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-binding hydrophobic groove
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06428019
disease_id_num_tar_ref
941
drug_id_num_tar_ref
2573