gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The LCMV-based vaccine expresses HPV16 E6/E7 to prime and expand HPV16-specific CD8+ T cells; these CTLs recognize E7 peptides on MHC I of tumor cells and kill them via perforin/granzyme (and Fas–FasL) pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Viral antigen presented as peptide–MHC class I complexes on HPV16-positive tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06513884
disease_id_num_tar_ref
948
drug_id_num_tar_ref
2589