gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific CD8+ T cells that kill cells presenting the specific neoantigen peptide on HLA class I (e.g., HLA-A) via perforin/granzyme or Fas–FasL. HLA-A alone is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide-MHC class I presentation; allele-restricted binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT03807102
disease_id_num_tar_ref
97
drug_id_num_tar_ref
253