gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Polatuzumab vedotin binds CD79b on B cells; after internalization it releases MMAE, which binds β-tubulin (Vinca site) to inhibit microtubule polymerization, causing G2/M arrest and apoptosis in CD79b+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds β-tubulin at the Vinca domain to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05633615
disease_id_num_tar_ref
952
drug_id_num_tar_ref
2600