gene_symbol
HLA-B
hgnc_id
HGNC:4932
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes/expands neoantigen-specific CD8+ T cells via APC presentation; these T cells kill tumor cells only if they present the specific neoantigen peptide on MHC I (e.g., HLA-B) via perforin/granzyme or Fas. HLA-B expression alone is not targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide-MHC class I presentation; allele-restricted binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT03807102
disease_id_num_tar_ref
97
drug_id_num_tar_ref
253