gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER3-binding IgG engages Fcγ receptors on effector cells to trigger ADCC, killing HER3+ cells; signaling blockade may add antiproliferative/pro-apoptotic effects.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks heregulin (NRG1) binding and HER2/EGFR–HER3 heterodimer signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06194656
disease_id_num_tar_ref
965
drug_id_num_tar_ref
2641