gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SIBP-03 binds HER3 on tumor cells; its Fc engages CD16A on NK cells to trigger ADCC against HER3-positive targets. CD16A-expressing cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement to trigger ADCC by NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06194656
disease_id_num_tar_ref
965
drug_id_num_tar_ref
2641