gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CD70 via the CAR, activating the T cells to kill CD70-positive cells through perforin/granzyme-mediated cytolysis and death receptor signaling.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as TNFSF7; membrane-bound ligand of CD27
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05948033
disease_id_num_tar_ref
966
drug_id_num_tar_ref
2643