gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD30 ADC binds CD30, is internalized, and releases MMAE intracellularly; MMAE inhibits tubulin polymerization, disrupting microtubules and causing G2/M arrest and apoptosis of CD30+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor targeted by the antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07074457
disease_id_num_tar_ref
968
drug_id_num_tar_ref
2655