gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-TROP2 ADC binds and is internalized; linker cleavage releases SN-38 (topoisomerase I inhibitor) in TROP2+ cells, causing DNA damage, replication arrest, and apoptosis; released payload can also cause bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Targeted by hRS7 monoclonal antibody component of the ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05675579
disease_id_num_tar_ref
975
drug_id_num_tar_ref
2671