gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds Trop-2 on tumor cells, is internalized, and releases SN-38, which inhibits topoisomerase I, causing DNA damage and apoptosis; released SN-38 can also kill nearby cells (bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibited by SN-38 payload released after internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05675579
disease_id_num_tar_ref
975
drug_id_num_tar_ref
2671