gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize the neoantigen–HLA (peptide–MHC) complex on target cells, form an immunologic synapse, and induce apoptosis via perforin/granzyme release and Fas–FasL signaling.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Patient-specific, HLA-restricted neoepitopes (1-5 per patient); class I/II depending on engineered TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05349890
disease_id_num_tar_ref
977
drug_id_num_tar_ref
2678