gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the HLA-A*11:01–presented KRAS G12V peptide and kill target cells via perforin/granzyme-mediated cytotoxicity (apoptosis).
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
TCR recognizes the KRAS G12V-derived peptide in the context of HLA-A*11:01 (pMHC complex)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06478251
disease_id_num_tar_ref
978
drug_id_num_tar_ref
2681