gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered TCR-T cells kill only tumor cells presenting the KRAS G12V peptide in HLA-A*11:01 via perforin/granzyme-mediated cytolysis; HLA-A*11:01 expression alone is not sufficient and is not a direct cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Restriction element of the pMHC complex presenting the KRAS G12V peptide
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06478251
disease_id_num_tar_ref
978
drug_id_num_tar_ref
2681