gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the KRAS G12D peptide presented by HLA-A*11:01 and, upon TCR engagement, kill the target cell via cytolytic granule release (perforin/granzymes) leading to apoptosis.
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide-MHC complex (pMHC) restricted by HLA-A*11:01
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06478251
disease_id_num_tar_ref
978
drug_id_num_tar_ref
2682