gene_symbol
CCR7
hgnc_id
HGNC:1608
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CCR7+ cells are not targeted. The CAR-T cells kill CD19+ cells via CAR-mediated T-cell cytotoxicity (perforin/granzyme). CCL19 secretion binds CCR7 to recruit and support immune cells, not to kill them.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor for secreted CCL19; mediates lymphocyte and dendritic cell trafficking
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06464861
disease_id_num_tar_ref
985
drug_id_num_tar_ref
2701