gene_symbol
HLA-DQB1
hgnc_id
HGNC:4944
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific CD8+ T cells via dendritic cell presentation; these CTLs kill tumor cells presenting neoantigen peptides on MHC I (perforin/granzyme). HLA-DQ–expressing cells are not specifically targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide-MHC class II presentation to CD4+ T cells; allele-restricted binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT03807102
disease_id_num_tar_ref
97
drug_id_num_tar_ref
253