gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD20 on B cells, inducing direct caspase-independent cell death and recruiting FcγRIIIa-expressing effector cells (e.g., NK cells, macrophages) to mediate ADCC/ADCP, leading to B-cell killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 binding; induces direct cell death and enables Fc-mediated effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06333262
disease_id_num_tar_ref
991
drug_id_num_tar_ref
2715