gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16b+ cells are not targeted; Obinutuzumab binds CD20 on B cells and engages Fc gamma RIII (CD16) on effector cells to trigger ADCC/ADCP and direct caspase-independent death of CD20+ B cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement; enhanced binding relative to non-glycoengineered antibodies
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06333262
disease_id_num_tar_ref
991
drug_id_num_tar_ref
2715