gene_symbol
MICA
hgnc_id
HGNC:7090
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
NKG2D CAR–NK cells bind MICA on target cells and signal via DAP10/CD3ζ to activate NK degranulation, releasing perforin and granzymes that induce cytolysis/apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand (stress-inducible)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05734898
disease_id_num_tar_ref
994
drug_id_num_tar_ref
2722