gene_symbol
ULBP1
hgnc_id
HGNC:14893
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
NKG2D CAR on NK cells binds ULBP1 on target cells and signals via DAP10/CD3ΞΆ, triggering NK degranulation (perforin/granzymes) and death receptor pathways to kill the ULBP1+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand (stress-inducible)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05734898
disease_id_num_tar_ref
994
drug_id_num_tar_ref
2722