gene_symbol
RAET1E
hgnc_id
HGNC:16793
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
NKG2D CAR on NK cells binds ULBP4 on target cells, signaling via DAP10/CD3ΞΆ to activate NK degranulation and kill via perforin/granzyme-mediated apoptosis (with possible FasL/TRAIL contributions).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand (stress-inducible); alias ULBP4
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05734898
disease_id_num_tar_ref
994
drug_id_num_tar_ref
2722