gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocking CD47–SIRPα removes the 'don’t‑eat‑me' signal, enabling macrophage-mediated phagocytosis of CD47+ cells; secondarily can augment T‑cell–mediated killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks the CD47–SIRPA interaction (innate immune checkpoint)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05835011
disease_id_num_tar_ref
1001
drug_id_num_tar_ref
2739