gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IL-3–diphtheria toxin fusion binds CD123, is internalized, and the toxin ADP-ribosylates EF-2 to block protein synthesis, causing death of CD123+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05716009
disease_id_num_tar_ref
1004
drug_id_num_tar_ref
2746