gene_symbol
EEF2
hgnc_id
HGNC:3214
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Tagraxofusp binds CD123 (not EF-2); after CD123-mediated internalization, its diphtheria toxin moiety ADP-ribosylates EF-2 to halt protein synthesis and kill CD123-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular ADP-ribosylation substrate of diphtheria toxin catalytic domain; inhibition of protein synthesis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05716009
disease_id_num_tar_ref
1004
drug_id_num_tar_ref
2746