gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD33 ADC binds CD33, is internalized, and releases calicheamicin, which binds the DNA minor groove to cause double-strand breaks and apoptosis in CD33+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface myeloid antigen; ADC antibody target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05716009
disease_id_num_tar_ref
1004
drug_id_num_tar_ref
2747