gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets CD33 on AML cells; after internalization it releases calicheamicin, which binds the DNA minor groove and causes double-strand breaks leading to apoptosis. DNA minor groove is not the selecting (antibody) target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin payload target; induces DNA double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05716009
disease_id_num_tar_ref
1004
drug_id_num_tar_ref
2747