gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific binds CD3ε on T cells to activate and redirect them; the activated T cells kill CD19+ tumor cells (perforin/granzyme). CD3ε-expressing T cells are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engages T cells via CD3 complex to trigger activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06580301
disease_id_num_tar_ref
101
drug_id_num_tar_ref
263